PTPRF and INPP5B

		PTPRF	INPP5B
Description		protein tyrosine phosphatase receptor type F	inositol polyphosphate-5-phosphatase B
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome	Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Metal Ion Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding	In Utero Embryonic Development Signal Transduction Spermatogenesis Flagellated Sperm Motility Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Regulation Of Protein Processing
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
Drugs			D-Myo-Inositol-1,4-Bisphosphate
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444 33495439) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autoimmune thyroid disease ( 32581359) Blood protein levels ( 30072576) Eyebrow thickness ( 26926045) Height ( 31562340) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Pulse pressure ( 28739976) Red cell distribution width ( 27863252) Rheumatoid arthritis ( 30423114 24390342) Type 1 diabetes ( 34012112)
Interacting Genes		68 interacting genes: ABCG1 ACAN ACAT1 ACTB ALDH1A1 ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INPP5B INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB LINC01587 MPL MYCBP NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B UROD VCAN YBX1 ZMPSTE24 ZNF512B	3 interacting genes: APP PTPRF SMURF1
Entrez ID		5792	3633
HPRD ID		01552	00924
Ensembl ID		ENSG00000142949	ENSG00000204084
Uniprot IDs		G1UI20 P10586	B3KMW4 P32019
PDB IDs		1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW	3MTC 3N9V 4CML 5A7I 5A7J
Enriched GO Terms of Interacting Partners?
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