PTPRF and PPFIA1

Number of citations of the paper that reports this interaction (PubMedID 9624153)
94

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PTPRF	PPFIA1
Description		protein tyrosine phosphatase receptor type F	PTPRF interacting protein alpha 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding	Cell-matrix Adhesion Signal Transduction Synapse Organization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444 33495439) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)	Coronary artery disease ( 29212778) Lymphocyte counts ( 32888494)
Interacting Genes		68 interacting genes: ABCG1 ACAN ACAT1 ACTB ALDH1A1 ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INPP5B INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB LINC01587 MPL MYCBP NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B UROD VCAN YBX1 ZMPSTE24 ZNF512B	31 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GAS8 GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS SHANK2 TNNT1 TXLNA YWHAG
Entrez ID		5792	8500
HPRD ID		01552	11451
Ensembl ID		ENSG00000142949	ENSG00000131626
Uniprot IDs		G1UI20 P10586	B3KVS8 Q13136
PDB IDs		1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW	1N7F
Enriched GO Terms of Interacting Partners?
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