PTPRF and ARHGEF2

  • Number of citations of the paper that reports this interaction (PubMedID 25458010)
  • 29
  • Data Source:
  • BioGRID (affinity chromatography technology, two hybrid, pull down)

PTPRF

ARHGEF2

Description protein tyrosine phosphatase receptor type F Rho/Rac guanine nucleotide exchange factor 2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adventurousness ( 30643258)
  • Amyotrophic lateral sclerosis (age of onset) ( 22959728)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Attention deficit hyperactivity disorder ( 30478444 33495439)
  • Attention deficit hyperactivity disorder or cannabis use ( 30610198)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Coffee consumption ( 31046077)
  • Cognitive ability (MTAG) ( 29186694)
  • Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439)
  • Educational attainment ( 27046643)
  • General cognitive ability ( 29844566)
  • General risk tolerance (MTAG) ( 30643258)
  • Household income (MTAG) ( 31844048)
  • Intake of total sugars ( 31005972)
  • Intelligence (MTAG) ( 29326435)
  • Mean reticulocyte volume ( 32888494)
  • Refractive error ( 32231278)
  • Schizophrenia ( 28991256 25056061 29483656 30285260)
  • Smoking initiation ( 30617275 33082346)
  • Smoking initiation (ever regular vs never regular) ( 30679032)
  • Stroke ( 29531354)
  • Urate levels ( 31578528)
  • Amyotrophic lateral sclerosis (age of onset) ( 22959728)
  • Body fat distribution (leg fat ratio) ( 30664634)
  • Body fat distribution (trunk fat ratio) ( 30664634)
  • Body size at age 10 ( 32376654)
  • Brain morphology (min-P) ( 32665545)
  • Brain morphology (MOSTest) ( 32665545)
  • Cortical surface area (min-P) ( 32665545)
  • Cortical surface area (MOSTest) ( 32665545)
  • Cortical thickness (min-P) ( 32665545)
  • Cortical thickness (MOSTest) ( 32665545)
  • Crohn's disease ( 28067908)
  • Inflammatory bowel disease ( 28067908)
  • Neuritic plaque ( 31497858)
  • Subcortical volume (min-P) ( 32665545)
  • Subcortical volume (MOSTest) ( 32665545)
Interacting Genes 68 interacting genes: ABCG1 ACAN ACAT1 ACTB ALDH1A1 ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INPP5B INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB LINC01587 MPL MYCBP NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B UROD VCAN YBX1 ZMPSTE24 ZNF512B 13 interacting genes: CGN MARK3 NFKBID PAK1 PTPRF RAC1 RHOA RPP25L RRAS2 YWHAE YWHAG YWHAQ YWHAZ
Entrez ID 5792 9181
HPRD ID 01552 10458
Ensembl ID ENSG00000142949 ENSG00000116584
Uniprot IDs G1UI20 P10586 A0A5F9ZI21 Q92974
PDB IDs 1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW 5EFX
Enriched GO Terms of Interacting Partners?
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