JAK1 and IL3RA

Number of citations of the paper that reports this interaction (PubMedID 15988755)
5

Data Source:
HPRD (in vivo)

		JAK1	IL3RA
Description		Janus kinase 1	interleukin 3 receptor subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Focal Adhesion Membrane	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding CCR5 Chemokine Receptor Binding Metal Ion Binding	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Protein Phosphorylation Receptor Signaling Pathway Via JAK-STAT Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Intracellular Signal Transduction Interleukin-2-mediated Signaling Pathway Response To Antibiotic Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Interleukin-6-mediated Signaling Pathway Protein Localization To Cell-cell Junction Positive Regulation Of Sprouting Angiogenesis	Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling Regulation of IFNA signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Myricetin 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Fedratinib Filgotinib Upadacitinib Pralsetinib	Sargramostim Tagraxofusp
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Cognitive function in longevity ( 33607172) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Liver enzyme levels (alkaline phosphatase) ( 33972514) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Plasma anti-thyroglobulin levels ( 29678681) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252)	Schizophrenia ( 17522711)
Interacting Genes		81 interacting genes: ABL1 AGTR1 ANKRD13C BRCA1 BTK CBR1 CCR1 CCR5 CSF2RB CSF3R CXCR4 DAB1 DHX9 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK2 JAK3 JAKMIP1 MDK NFYC OSMR P2RY1 P3H1 PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2 USP6 VNN2	32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5
Entrez ID		3716	3563
HPRD ID		00992	02392
Ensembl ID		ENSG00000162434	ENSG00000185291
Uniprot IDs		P23458 Q6P669	P26951
PDB IDs		3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D 6RSB 6RSC 6RSD 6RSE 6RSH 6SM8 6SMB 6TPE 6TPF 6W8L	4JZJ 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?
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