JAK1 and STAT3

  • Number of citations of the paper that reports this interaction (PubMedID 8272872)
  • 187
  • Data Source:
  • BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)
  • HPRD (in vitro, in vivo)

JAK1

STAT3

Description Janus kinase 1 signal transducer and activator of transcription 3
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Interacting Genes 81 interacting genes: ABL1 AGTR1 ANKRD13C BRCA1 BTK CBR1 CCR1 CCR5 CSF2RB CSF3R CXCR4 DAB1 DHX9 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK2 JAK3 JAKMIP1 MDK NFYC OSMR P2RY1 P3H1 PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2 USP6 VNN2 211 interacting genes: ABL2 ADRB2 AMBP AR ARFIP2 ASXL1 ATF3 BATF3 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 BRWD1 CA8 CAPN1 CAPNS1 CBL CCDC87 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CHTF18 CNDP2 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX DOK2 DOK3 DTNA ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBIN ESR1 FAM117B FBXW7 FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GAS5 GATA1 GATA2 GHR GNL3 GSTCD GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HESX1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IMPDH2 IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KLF15 KPNA1 KPNA6 KRTAP10-7 LAMB2 LASP1 LCK LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MEG3 MET MNDA MORC4 MPZL1 MRPS31 MTOR MYOD1 NACAD NCOA1 NDUFA13 NFE2L2 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 NUFIP2 NXT2 OFCC1 OGDHL PAFAH1B2 PAQR7 PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PIK3R1 PIK3R2 PIK3R3 PINK1 PML POM121 PPARD PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RABGAP1 RAC1 RACK1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 RRAD SCAF11 SETD7 SH2D2A SH3BP2 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TAB3 TASOR2 TDG TM4SF19 TRIM28 TRIP10 TSHR TSLP TWIST1 VPS39 WDFY3 ZFPM2 ZNF148 ZNF281 ZNF467 ZNF557 ZNF829 ZNRD2
Entrez ID 3716 6774
HPRD ID 00992 00026
Ensembl ID ENSG00000162434 ENSG00000168610
Uniprot IDs P23458 Q6P669 A0A7I2V395 P40763
PDB IDs 3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D 6RSB 6RSC 6RSD 6RSE 6RSH 6SM8 6SMB 6TPE 6TPF 6W8L 5AX3 5U5S 6NJS 6NUQ 6QHD 6TLC
Enriched GO Terms of Interacting Partners?
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