IL3RA and SAE1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		IL3RA	SAE1
Description		interleukin 3 receptor subunit alpha	SUMO1 activating enzyme subunit 1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Protein Ubiquitination Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs		Sargramostim Tagraxofusp
Diseases
GWAS		Schizophrenia ( 17522711)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	22 interacting genes: AGTR1 APP CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39
Entrez ID		3563	10055
HPRD ID		02392	18010
Ensembl ID		ENSG00000185291	ENSG00000142230
Uniprot IDs		P26951	A0A024R0R4 Q9UBE0
PDB IDs		4JZJ 5UV8 5UWC 6NMY	1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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