IL3RA and CISH

Number of citations of the paper that reports this interaction (PubMedID 7796808)
133

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IL3RA	CISH
Description		interleukin 3 receptor subunit alpha	cytokine inducible SH2 containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs		Sargramostim Tagraxofusp
Diseases
GWAS		Schizophrenia ( 17522711)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	18 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR GPX1 HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		3563	1154
HPRD ID		02392	03897
Ensembl ID		ENSG00000185291	ENSG00000114737
Uniprot IDs		P26951	Q9NSE2
PDB IDs		4JZJ 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?
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