PDGFRB and PDGFD

Number of citations of the paper that reports this interaction (PubMedID 14514732)
19

Data Source:
HPRD (in vivo)

		PDGFRB	PDGFD
Description		platelet derived growth factor receptor beta	platelet derived growth factor D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Intrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Lysosomal Lumen Intracellular Membrane-bounded Organelle Receptor Complex	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Enzyme Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Phosphatidylinositol 3-kinase Binding Platelet-derived Growth Factor Binding	Platelet-derived Growth Factor Receptor Binding Growth Factor Activity Growth Factor Receptor Binding
	Biological Process	Angiogenesis Glycosaminoglycan Biosynthetic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Aging Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Response To Estradiol Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Kinase Activity Response To Fluid Shear Stress Positive Regulation Of Rho Protein Signal Transduction Cell Migration Involved In Vasculogenesis Metanephric Mesenchymal Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Mitotic Nuclear Division Phosphatidylinositol Metabolic Process Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Inner Ear Development Positive Regulation Of Chemotaxis Cardiac Myofibril Assembly Response To Hyperoxia Cell Chemotaxis Lung Growth Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Mesenchyme Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of DNA Biosynthetic Process	Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of MAP Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Cellular Response To Hydrogen Peroxide Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Monocyte Extravasation
Pathways		PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Signaling by PDGF
Drugs		Becaplermin Sorafenib Imatinib Dasatinib Sunitinib XL999 XL820 Pazopanib Midostaurin Regorafenib Nintedanib Polaprezinc Trapidil Foreskin fibroblast (neonatal) Fostamatinib Erdafitinib Pexidartinib Ripretinib Pralsetinib	CR002 Tandutinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) Brain asymmetrical skew (vertical) ( 33836062) Coronary artery disease ( 32469254 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378988) Cortical surface area (visual PC2) ( 32198502) Cortical volume ( 32963231) Corticosteroid-induced adrenal suppression (peak cortisol < 350 nmol/L) ( 29551627) Corticosteroid-induced adrenal suppression (peak cortisol < 500 nmol/L) ( 29551627) Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) LDL cholesterol ( 21347282) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Myocardial infarction ( 33532862 26343387) Neutrophil count ( 21507922) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Response to lurasidone in schizophrenia ( 29730043) Self-reported risk-taking behaviour ( 30271922) Toenail selenium levels ( 25343990) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		84 interacting genes: ABL1 ABL2 ARAF BAG1 CAV1 CAV3 CBL CDK14 CDX1 CEP76 CHRM3 COPA COPB1 CRK EGFR EIF2AK2 ERBB2 FAXDC2 FGFR1 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 ITK JAK1 JAK2 KLHL12 KPRP KRT31 KRT34 KRTAP10-9 KRTAP12-3 KRTAP4-12 MITF NCK1 NCK2 NEDD4 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PPM1L PRDX2 PTEN PTK2 PTPN1 PTPN11 PTPN2 PTPN6 PTPRJ RAF1 RASA1 RPS6KB2 S1PR1 SHC1 SLC9A3R1 SLC9A3R2 SNX1 SNX2 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TNK2 TPTE TRIP6 TUFM TYK2 VAV1 YES1	1 interacting genes: PDGFRB
Entrez ID		5159	80310
HPRD ID		01423	17830
Ensembl ID		ENSG00000113721	ENSG00000170962
Uniprot IDs		P09619 Q59F04	Q9GZP0
PDB IDs		1GQ5 1H9O 1LWP 1SHA 2IUI 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?
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