IRF2 and HMGN1

Number of citations of the paper that reports this interaction (PubMedID 11025449)
11

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		IRF2	HMGN1
Description		interferon regulatory factor 2	high mobility group nucleosome binding domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of NAD+ ADP-ribosyltransferase Activity
Pathways		Pyroptosis Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases
GWAS		Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978) Type 1 diabetes ( 34012112)	Apolipoprotein A1 levels ( 33730874) LDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		24 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFE2L2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63	26 interacting genes: CAMSAP3 CDC42 CHEK2 EP300 ETS2 GSK3A HMGN2 HPF1 IRF2 KLF13 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 TMEM121B YWHAZ
Entrez ID		3660	3150
HPRD ID		00962	01231
Ensembl ID		ENSG00000168310	ENSG00000205581
Uniprot IDs		P14316	P05114 Q6NSG7
PDB IDs
Enriched GO Terms of Interacting Partners?
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