IRF2 and IRF2BP2

Number of citations of the paper that reports this interaction (PubMedID 12799427)
50

Data Source:
HPRD (two hybrid, in vivo)

		IRF2	IRF2BP2
Description		interferon regulatory factor 2	interferon regulatory factor 2 binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Immature B Cell Differentiation Regulation Of Transcription By RNA Polymerase II
Pathways		Pyroptosis Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978) Type 1 diabetes ( 34012112)	Age at first sexual intercourse ( 34211149) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 22688191) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 32203549 28334899) Life threatening arrhythmia ( 22247754) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Spleen volume ( 34128465) Total cholesterol levels ( 28334899) White blood cell count (eosinophil) ( 28158719)
Interacting Genes		24 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFE2L2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63	7 interacting genes: ERBB2 ERBB3 ERBB4 IRF2 MAILR MTNR1B NFATC2
Entrez ID		3660	359948
HPRD ID		00962	17160
Ensembl ID		ENSG00000168310	ENSG00000168264
Uniprot IDs		P14316	Q7Z5L9
PDB IDs
Enriched GO Terms of Interacting Partners?
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