DOK2 and RET

Number of citations of the paper that reports this interaction (PubMedID 11470823)
43

Data Source:
HPRD (two hybrid)

		DOK2	RET
Description		docking protein 2	ret proto-oncogene
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Membrane Raft Plasma Membrane Protein Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Posterior Midgut Development Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Protein Kinase B Signaling Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Tie2 Signaling RET signaling	RAF/MAP kinase cascade RET signaling
Drugs			Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Entorhinal cortical thickness ( 21116278) Lymphocyte counts ( 32888494) Mean corpuscular volume ( 20139978) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neuropathic pain in type 2 diabetes ( 24974787) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 30206226) Platelet distribution width ( 32888494) Refractive error ( 32231278) Verbal declarative memory ( 25648963)	Blood protein levels ( 30072576 29875488 28240269) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 30031151 25310821 29379196 27702942) Smoking behaviour (cigarettes smoked per day) ( 31089300)
Interacting Genes		22 interacting genes: ABL1 APPL1 CRK CRKL CSK DOK3 EGFR HCK IL4R INPP5D KIFBP LCK LYN NCK1 POT1 RASA1 RET SRC STAT3 TEK TXK YES1	44 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SRC STAT3
Entrez ID		9046	5979
HPRD ID		05411	01266
Ensembl ID		ENSG00000147443	ENSG00000165731
Uniprot IDs		B4DKQ6 O60496	A0A024R7T2 P07949
PDB IDs		2D9W 2DLW	1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG 7JU5 7JU6
Enriched GO Terms of Interacting Partners?
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