CISH and PRLR

Number of citations of the paper that reports this interaction (PubMedID 11713228)
15

Data Source:
HPRD (in vivo)

		CISH	PRLR
Description		cytokine inducible SH2 containing protein	prolactin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex
	Molecular Function	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Prolactin Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Prolactin Signaling Pathway Oncostatin-M-mediated Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Leukemia Inhibitory Factor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Interleukin-7 signaling Neddylation Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		18 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR GPX1 HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2	22 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 ICAM3 INSIG2 JAK2 MFGE8 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		1154	5618
HPRD ID		03897	01457
Ensembl ID		ENSG00000114737	ENSG00000113494
Uniprot IDs		Q9NSE2	P16471
PDB IDs			1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?
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