CISH and EPOR

Number of citations of the paper that reports this interaction (PubMedID 7796808)
133

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		CISH	EPOR
Description		cytokine inducible SH2 containing protein	erythropoietin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization
Pathways		Interleukin-7 signaling Neddylation Growth hormone receptor signaling	Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		18 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR GPX1 HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2	40 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 ICAM3 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL
Entrez ID		1154	2057
HPRD ID		03897	00587
Ensembl ID		ENSG00000114737	ENSG00000187266
Uniprot IDs		Q9NSE2	P19235
PDB IDs			1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL
Enriched GO Terms of Interacting Partners?
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