AOX1 and RCHY1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		AOX1	RCHY1
Description		aldehyde oxidase 1	ring finger and CHY zinc finger domain containing 1
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	Aldehyde Oxidase Activity Iron Ion Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding NAD Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding Geranial:oxygen Oxidoreductase Activity Heptaldehyde:oxygen Oxidoreductase Activity	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Xenobiotic Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Translesion Synthesis
Pathways		Vitamins B6 activation to pyridoxal phosphate	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Cyclobenzaprine Eniluracil
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)	Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		8 interacting genes: ABCA1 BCS1L CRKL CTLA4 ERRFI1 GK RBL1 RCHY1	75 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160
Entrez ID		316	25898
HPRD ID		07537	07607
Ensembl ID		ENSG00000138356	ENSG00000163743
Uniprot IDs		Q06278	Q96PM5
PDB IDs		4UHW 4UHX 5EPG 6Q6Q	2JRJ 2K2C 2K2D
Enriched GO Terms of Interacting Partners?
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