AOX1 and CTLA4

		AOX1	CTLA4
Description		aldehyde oxidase 1	cytotoxic T-lymphocyte associated protein 4
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion
	Molecular Function	Aldehyde Oxidase Activity Iron Ion Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding NAD Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding Geranial:oxygen Oxidoreductase Activity Heptaldehyde:oxygen Oxidoreductase Activity	Protein Binding
	Biological Process	Xenobiotic Metabolic Process	Adaptive Immune Response Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Vitamins B6 activation to pyridoxal phosphate	CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs		Cyclobenzaprine Eniluracil	Ipilimumab Tremelimumab
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)	Addison's disease ( 33574239) Alopecia areata ( 20596022 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 30659077 21829393 25751624 19430480 30572963 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)
Interacting Genes		8 interacting genes: ABCA1 BCS1L CRKL CTLA4 ERRFI1 GK RBL1 RCHY1	27 interacting genes: AOX1 AP1M1 AP2M1 ATP5MC3 BCS1L CD28 CD80 CD86 CDC26 CLK1 CTXN3 DCTD FYN GLP1R JAK2 LCK LYN MALL PIK3R1 PLCL1 PPP2R5A PTPN11 SKP1 STAT5A STAT5B TMEM218 TXK
Entrez ID		316	1493
HPRD ID		07537	00474
Ensembl ID		ENSG00000138356	ENSG00000163599
Uniprot IDs		Q06278	P16410
PDB IDs		4UHW 4UHX 5EPG 6Q6Q	1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM 6XY2 7CIO
Enriched GO Terms of Interacting Partners?
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