CTLA4 and PLCL1

		CTLA4	PLCL1
Description		cytotoxic T-lymphocyte associated protein 4	phospholipase C like 1 (inactive)
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion	Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity GABA Receptor Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Adaptive Immune Response Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Lipid Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Phosphatidylinositol-mediated Signaling Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Receptor Binding
Pathways		CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs		Ipilimumab Tremelimumab	Quinacrine
Diseases
GWAS		Addison's disease ( 33574239) Alopecia areata ( 20596022 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 30659077 21829393 25751624 19430480 30572963 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)	Adult body size ( 32376654) Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31361310 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Brain cytoarchitecture ( 20308991) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Central retinal arteriolar equivalent ( 31597446) Chin dimples ( 27182965) Chronotype ( 30696823) Coronary artery disease ( 26708285) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Dermatomyositis ( 23983088) Educational attainment ( 23722424) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip bone size ( 18776929) Intracranial aneurysm ( 18997786) Low high density lipoprotein cholesterol levels ( 26879886) Menarche (age at onset) ( 27182965 21102462) Mood instability ( 31168069) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Neutrophil count ( 21507922) Rheumatoid arthritis ( 32868391 30891314) Schizophrenia ( 25056061 29483656 30285260) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sun-seeking behavior ( 32920024) Systemic lupus erythematosus ( 33536424 28714469) Total body bone mineral density ( 29304378) Ulcerative colitis ( 23128233) Urinary sodium excretion ( 31409800) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		27 interacting genes: AOX1 AP1M1 AP2M1 ATP5MC3 BCS1L CD28 CD80 CD86 CDC26 CLK1 CTXN3 DCTD FYN GLP1R JAK2 LCK LYN MALL PIK3R1 PLCL1 PPP2R5A PTPN11 SKP1 STAT5A STAT5B TMEM218 TXK	1 interacting genes: CTLA4
Entrez ID		1493	5334
HPRD ID		00474	07041
Ensembl ID		ENSG00000163599	ENSG00000115896
Uniprot IDs		P16410	Q15111
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM 6XY2 7CIO
Enriched GO Terms of Interacting Partners?
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