CTLA4 and DCTD

		CTLA4	DCTD
Description		cytotoxic T-lymphocyte associated protein 4	dCMP deaminase
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion	Cytosol
	Molecular Function	Protein Binding	DCMP Deaminase Activity Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Pyrimidine Nucleotide Metabolic Process DUMP Biosynthetic Process DTMP Biosynthetic Process
Pathways		CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Interconversion of nucleotide di- and triphosphates
Drugs		Ipilimumab Tremelimumab
Diseases
GWAS		Addison's disease ( 33574239) Alopecia areata ( 20596022 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 30659077 21829393 25751624 19430480 30572963 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)	Diisocyanate-induced asthma ( 25918132) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Wegener's granulomatosis ( 23740775)
Interacting Genes		27 interacting genes: AOX1 AP1M1 AP2M1 ATP5MC3 BCS1L CD28 CD80 CD86 CDC26 CLK1 CTXN3 DCTD FYN GLP1R JAK2 LCK LYN MALL PIK3R1 PLCL1 PPP2R5A PTPN11 SKP1 STAT5A STAT5B TMEM218 TXK	15 interacting genes: CEP76 CTLA4 FGF12 FXR1 FXR2 GORASP2 LNX1 MALSU1 NIF3L1 NUDT18 PICK1 PSMA1 SDCBP TXN2 UBE2I
Entrez ID		1493	1635
HPRD ID		00474	09623
Ensembl ID		ENSG00000163599	ENSG00000129187
Uniprot IDs		P16410	P32321
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM 6XY2 7CIO	2W4L
Enriched GO Terms of Interacting Partners?
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