KCNIP3 and MAVS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		KCNIP3	MAVS
Description		potassium voltage-gated channel interacting protein 3	mitochondrial antiviral signaling protein
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding	Protein Binding Protein Kinase Binding Signaling Adaptor Activity CARD Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Signal Transduction Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization
Pathways		Phase 1 - inactivation of fast Na+ channels	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Platelet distribution width ( 32888494)
Interacting Genes		27 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CFLAR CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	24 interacting genes: ABL1 CCDC50 DDX3X DDX58 FASTKD5 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP1LC3A MAP3K7 OAS3 OTUD4 RIPK2 RNF115 RNF34 RNF5 SMURF2 STAT1 TBK1 TICAM1 TRAF6 UBE4A
Entrez ID		30818	57506
HPRD ID		05232	13847
Ensembl ID		ENSG00000115041	ENSG00000088888
Uniprot IDs		A0A024RE22 Q9Y2W7	Q7Z434
PDB IDs		2E6W	2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK
Enriched GO Terms of Interacting Partners?
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