HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
MAVS and STAT1
Number of citations of the paper that reports this interaction (PubMedID
21903422
)
143
Data Source:
BioGRID
(pull down)
MAVS
STAT1
Description
mitochondrial antiviral signaling protein
signal transducer and activator of transcription 1
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Outer Membrane
Peroxisomal Membrane
Integral Component Of Membrane
Mitochondrial Membrane
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Protein Kinase Binding
Signaling Adaptor Activity
CARD Domain Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Nuclear Receptor Binding
Enzyme Binding
CCR5 Chemokine Receptor Binding
Histone Acetyltransferase Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Protein Phosphatase 2A Binding
Promoter-specific Chromatin Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Signal Transduction
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Response To Cytokine Stimulus
Cellular Response To Exogenous DsRNA
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of IP-10 Production
Regulation Of Peroxisome Organization
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Defense Response
Receptor Signaling Pathway Via JAK-STAT
Response To Nutrient
Blood Circulation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-alpha Production
Cellular Response To Insulin Stimulus
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Interferon-beta
Cellular Response To Interferon-beta
Regulation Of Cell Population Proliferation
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To CAMP
Defense Response To Virus
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Renal Tubule Development
Interleukin-27-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Cellular Response To Organic Cyclic Compound
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ovarian tumor domain proteases
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Drugs
Diseases
GWAS
Platelet distribution width (
32888494
)
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
28425483
26394269
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Interacting Genes
24 interacting genes:
ABL1
CCDC50
DDX3X
DDX58
FASTKD5
IKBKB
IRF3
IRF5
IRF7
KCNIP3
MAP1LC3A
MAP3K7
OAS3
OTUD4
RIPK2
RNF115
RNF34
RNF5
SMURF2
STAT1
TBK1
TICAM1
TRAF6
UBE4A
109 interacting genes:
ACTN4
ADRA1B
AKT1
ATF3
BMX
BRCA1
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MFSD6
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIK3CA
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT4
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
Entrez ID
57506
6772
HPRD ID
13847
02777
Ensembl ID
ENSG00000088888
ENSG00000115415
Uniprot IDs
Q7Z434
P42224
PDB IDs
2MS7
2MS8
2VGQ
3J6C
3J6J
3RC5
4P4H
4Z8M
5JEK
1BF5
1YVL
2KA6
3WWT
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?