KCNIP3 and CDSN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KCNIP3	CDSN
Description		potassium voltage-gated channel interacting protein 3	corneodesmosin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus	Cornified Envelope Extracellular Region Plasma Membrane Cell-cell Junction Desmosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding	Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Corneocyte Desquamation Cell Adhesion Epidermis Development Keratinocyte Differentiation Skin Morphogenesis Cell-cell Adhesion Negative Regulation Of Cornification
Pathways		Phase 1 - inactivation of fast Na+ channels	Formation of the cornified envelope
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 28240269) Hematology traits ( 23263863) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Multiple myeloma ( 23955597) Schizophrenia ( 28991256) Systemic mastocytosis ( 32752121) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) White blood cell count ( 20139978 21738480)
Interacting Genes		27 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CFLAR CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	39 interacting genes: ACE2 ASPH ATXN1L BAG6 BANP CCHCR1 CEP55 CSTF2 CSTF2T CTNNA3 DAXX DESI1 EIF3F ENKD1 EXOC8 FAM9B HGS HPCAL4 ITPRIPL1 KCNIP3 KLK7 LCN2 NCS1 NELFCD PARVG PLVAP PRKAB2 SGTA SGTB SMARCD1 TGM7 TRIM69 TSGA10 UBQLN1 UBQLN2 UBQLN4 UCHL5 VSNL1 ZDHHC17
Entrez ID		30818	1041
HPRD ID		05232	03998
Ensembl ID		ENSG00000115041	ENSG00000204539
Uniprot IDs		A0A024RE22 Q9Y2W7	G8JLG2 Q15517
PDB IDs		2E6W
Enriched GO Terms of Interacting Partners?
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