TIMM22 and PDCD6

Number of citations of the paper that reports this interaction (PubMedID 11591653)
42

Data Source:
HPRD (in vitro)

		TIMM22	PDCD6
Description		translocase of inner mitochondrial membrane 22	programmed cell death 6
Image
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Integral Component Of Membrane TIM22 Mitochondrial Import Inner Membrane Insertion Complex	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Protein Transporter Activity	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Protein Insertion Into Mitochondrial Inner Membrane Protein Transmembrane Transport	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination
Pathways		Mitochondrial protein import Mitochondrial protein import
Drugs			Calcium Zinc Calcium citrate Calcium Phosphate Calcium phosphate dihydrate Zinc acetate
Diseases
GWAS			Eye color ( 33692100) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: CYSRT1 PDCD6 REEP4 TMEM14B	28 interacting genes: ANXA11 ANXA7 BAG4 CDKN2A CPNE1 CPNE2 CPNE4 CUL3 DIAPH3 FAS FASLG FNDC3A HEBP2 IGFALS MAP3K5 MAPK1IP1L MIA2 PDCD6IP PEF1 PRR19 SARAF SEC31A SH3KBP1 SHISA4 TERT TIMM22 VPS37C YWHAQ
Entrez ID		29928	10016
HPRD ID		06262	03035
Ensembl ID		ENSG00000177370	ENSG00000249915
Uniprot IDs		Q9Y584	A0A024QZ42 A0A087WZ38 O75340 Q53FC3
PDB IDs		7CGP	2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ
Enriched GO Terms of Interacting Partners?
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