GRIK2 and DLG3

Number of citations of the paper that reports this interaction (PubMedID 9808460)
71

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		GRIK2	DLG3
Description		glutamate ionotropic receptor kainate type subunit 2	discs large MAGUK scaffold protein 3
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Postsynaptic Membrane	Extracellular Space Cytosol Plasma Membrane Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Growth Cone AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Protein C-terminus Binding Kinase Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Excitatory Postsynaptic Potential Detection Of Cold Stimulus Involved In Thermoception	Establishment Of Planar Polarity Negative Regulation Of Cell Population Proliferation Embryo Development Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure
Pathways		Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Biochemical measures ( 19260141) Body shape index ( 34021172) Cardiac hypertrophy ( 21348951) Emphysema imaging phenotypes ( 26030696) Heart rate response to recovery post exercise (20 sec) ( 29497042) Longevity (90 years and older) ( 25199915) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) levels ( 23362303) Pursuit maintenance gain ( 29064472) Renal function-related traits (eGRFcrea) ( 22797727) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196)	Mean platelet volume ( 32888494)
Interacting Genes		18 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25	49 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN
Entrez ID		2898	1741
HPRD ID		00692	02177
Ensembl ID		ENSG00000164418	ENSG00000082458
Uniprot IDs		A8K0H7 Q13002 Q8IY40	Q59FY1 Q92796
PDB IDs		3QXM 5CMM	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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