SPCS1 and NAALAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPCS1	NAALAD2
Description		signal peptidase complex subunit 1	N-acetylated alpha-linked acidic dipeptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function Protein Binding Peptidase Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Dipeptidase Activity Metal Ion Binding
	Biological Process	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER	Proteolysis
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Aspartate and asparagine metabolism
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256 25056061 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)
Interacting Genes		10 interacting genes: AQP2 FIS1 FXYD6-FXYD2 NAALAD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2	4 interacting genes: CIDEB RHBDD2 SMIM1 SPCS1
Entrez ID		28972	10003
HPRD ID		07155	07494
Ensembl ID		ENSG00000114902	ENSG00000077616
Uniprot IDs		Q9Y6A9	J3KNJ3 Q9Y3Q0
PDB IDs			3FEC 3FED 3FEE 3FF3
Enriched GO Terms of Interacting Partners?
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