SPCS1 and YIPF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPCS1	YIPF2
Description		signal peptidase complex subunit 1	Yip1 domain family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Golgi Trans Cisterna Golgi Apparatus Golgi Medial Cisterna Trans-Golgi Network Integral Component Of Membrane Transport Vesicle Late Endosome Membrane
	Molecular Function	Molecular_function Protein Binding Peptidase Activity	Protein Binding Small GTPase Binding
	Biological Process	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER	Vesicle-mediated Transport
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256 25056061 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: AQP2 FIS1 FXYD6-FXYD2 NAALAD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2	24 interacting genes: AQP6 CREB3 ERGIC3 FATE1 FFAR2 GPR42 HSD17B13 LEPROTL1 MFSD14B PGRMC2 RNF185 RNF5 SHISAL2A SLC10A6 SLC30A2 SLC39A3 SPCS1 STING1 SYPL2 TMEM143 TMEM14B TMX2 TVP23B YIPF6
Entrez ID		28972	78992
HPRD ID		07155	11332
Ensembl ID		ENSG00000114902	ENSG00000130733
Uniprot IDs		Q9Y6A9	A0A024R7E1 K7ENM8 Q9BWQ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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