NAALAD2 and SPCS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NAALAD2	SPCS1
Description		N-acetylated alpha-linked acidic dipeptidase 2	signal peptidase complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Dipeptidase Activity Metal Ion Binding	Molecular_function Protein Binding Peptidase Activity
	Biological Process	Proteolysis	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER
Pathways		Aspartate and asparagine metabolism	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Adult body size ( 32376654) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256 25056061 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: CIDEB RHBDD2 SMIM1 SPCS1	10 interacting genes: AQP2 FIS1 FXYD6-FXYD2 NAALAD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2
Entrez ID		10003	28972
HPRD ID		07494	07155
Ensembl ID		ENSG00000077616	ENSG00000114902
Uniprot IDs		J3KNJ3 Q9Y3Q0	Q9Y6A9
PDB IDs		3FEC 3FED 3FEE 3FF3
Enriched GO Terms of Interacting Partners?
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