NAALAD2 and RHBDD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NAALAD2	RHBDD2
Description		N-acetylated alpha-linked acidic dipeptidase 2	rhomboid domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Golgi Membrane Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Dipeptidase Activity Metal Ion Binding	Serine-type Endopeptidase Activity Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Proteolysis	Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response
Pathways		Aspartate and asparagine metabolism
Drugs
Diseases
GWAS		Adult body size ( 32376654) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		4 interacting genes: CIDEB RHBDD2 SMIM1 SPCS1	58 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MFSD14C MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30
Entrez ID		10003	57414
HPRD ID		07494	11492
Ensembl ID		ENSG00000077616	ENSG00000005486
Uniprot IDs		J3KNJ3 Q9Y3Q0	Q6NTF9
PDB IDs		3FEC 3FED 3FEE 3FF3
Enriched GO Terms of Interacting Partners?
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