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GRN and SHANK3
Number of citations of the paper that reports this interaction (PubMedID
21653829
)
98
Data Source:
BioGRID
(two hybrid)
GRN
SHANK3
Description
granulin precursor
SH3 and multiple ankyrin repeat domains 3
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Cytosol
Postsynaptic Density
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuron Projection
Dendritic Spine
Neuron Spine
Postsynaptic Membrane
Ciliary Membrane
Molecular Function
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Chaperone Binding
Actin Binding
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SH3 Domain Binding
Synaptic Receptor Adaptor Activity
Ionotropic Glutamate Receptor Binding
Protein Self-association
Scaffold Protein Binding
Biological Process
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Axon Regeneration
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Protein Stabilization
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Aspartic-type Peptidase Activity
Positive Regulation Of Lysosome Organization
MAPK Cascade
Synapse Assembly
Learning
Memory
Striatal Medium Spiny Neuron Differentiation
Adult Behavior
Negative Regulation Of Actin Filament Bundle Assembly
Social Behavior
Vocal Learning
Negative Regulation Of Cell Volume
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Brain Morphogenesis
Positive Regulation Of Synapse Structural Plasticity
Positive Regulation Of Synaptic Transmission, Glutamatergic
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Development
Regulation Of Dendritic Spine Morphogenesis
Vocalization Behavior
Postsynaptic Density Assembly
AMPA Glutamate Receptor Clustering
NMDA Glutamate Receptor Clustering
Guanylate Kinase-associated Protein Clustering
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Glutamate Receptor Signaling Pathway
Regulation Of Long-term Synaptic Depression
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of AMPA Receptor Activity
Pathways
Neutrophil degranulation
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Extremely high intelligence (
29520040
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
26561523
)
Intelligence (MTAG) (
29326435
)
Mean platelet volume (
32888494
)
Memory dysfunction in frontotemporal lobe dementia (
29724592
)
Platelet count (
32888494
)
Interacting Genes
81 interacting genes:
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
MBD1
MEOX2
NLK
NUFIP2
OTX1
P4HB
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SHANK3
SLC13A1
SLPI
SMAD9
SMCP
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
156 interacting genes:
ABCC2
ABI1
ABI2
ACE2
ACTN2
ADGRL1
AGAP7P
ALDOA
ANKRD35
APP
ARHGAP44
ARPC2
ARPC5L
ATN1
BAIAP2
C1QBP
CA10
CALCOCO1
CAMK2B
CCT3
CENPJ
CEP72
CIBAR1
CLTA
CLU
CNKSR2
COPS5
COPS6
COQ5
CRELD1
CRKL
CSNK1D
CSNK2B
CTTN
CYP51A1
CYTIP
DBNL
DCTN2
DDB1
DLGAP1
DLGAP2
DLGAP3
DLGAP4
DNAJA3
DNM2
EFEMP1
EFEMP2
EID1
ELAVL1
ERI3
FAM13A
FBXO7
FKBP8
FRS3
FRYL
GAPDH
GOT1
GPR162
GPS1
GRB2
GRN
HAGH
HECW1
HGS
HNRNPK
HOMER3
ICA1
IGSF9
ITGBL1
ITSN1
JAG2
KHDRBS1
KIAA0232
LINGO1
LRRC73
LTBP3
LTBP4
LZTS2
LZTS3
MAPK1
MBIP
MBOAT7
MCRS1
MDH2
MEGF10
MEGF11
MEGF6
MIPOL1
MRM3
MT-CO2
MT-ND6
MYO5B
N4BP3
NCK1
NCKIPSD
NEFL
NGRN
NOTCH1
NOTCH2
NOTCH2NLA
NOTCH3
NR1D1
NRBF2
PAX6
PDHB
PFKL
PHF12
PHLDB1
PLEKHA4
PPHLN1
PPP1CC
PPP1R13L
PPP1R9B
PPP2R3B
PRMT2
QSOX1
RBM5
RPL3
RPS6KA1
RTN3
RUNDC3A
SCYL3
SETD2
SH3GL2
SH3GL3
SHANK1
SHARPIN
SIPA1
SLC48A1
SNRPN
SORBS2
SORBS3
SPAG5
SPTAN1
SRSF9
STK32C
SYNGAP1
SYT5
TCF25
TDRD7
TFIP11
THRAP3
TMEM14C
TNIP2
TRAF3
TRIM27
TRIM9
TRIP10
TSG101
TUBA1C
UCHL1
USP8
VIM
VPS18
WWP1
ZCCHC2
Entrez ID
2896
85358
HPRD ID
00733
18979
Ensembl ID
ENSG00000030582
ENSG00000251322
Uniprot IDs
P28799
PDB IDs
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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