GRN and PIK3R2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GRN	PIK3R2
Description		granulin precursor	phosphoinositide-3-kinase regulatory subunit 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome	Nucleus Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Chaperone Binding	Phosphotyrosine Residue Binding Protein Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity
	Biological Process	Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Aspartic-type Peptidase Activity Positive Regulation Of Lysosome Organization	Cellular Glucose Homeostasis Insulin Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Protein Transport Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		Neutrophil degranulation	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs			Isoprenaline SF1126
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887)
Interacting Genes		81 interacting genes: ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A MBD1 MEOX2 NLK NUFIP2 OTX1 P4HB PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SHANK3 SLC13A1 SLPI SMAD9 SMCP SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1	59 interacting genes: APP APPL1 AR ARRB1 AXL CBL CD28 CRK CRKL CSF1R DYDC1 EGF EGFR ENKUR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GAB1 GHR GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LMNA LTBP3 MET MRFAP1L1 PDGFRB PIK3CD RINT1 SEPTIN2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 STAT3 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID		2896	5296
HPRD ID		00733	04404
Ensembl ID		ENSG00000030582	ENSG00000105647
Uniprot IDs		P28799	O00459
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV 6NUG	2KT1 2XS6 3MTT 3O5Z 6OX7 6U28
Enriched GO Terms of Interacting Partners?
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