SHANK3 and NCK1

  • Number of citations of the paper that reports this interaction (PubMedID 21988832)
  • 87
  • Data Source:
  • BioGRID (two hybrid)

SHANK3

NCK1

Description SH3 and multiple ankyrin repeat domains 3 NCK adaptor protein 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199)
  • Blood urea nitrogen levels ( 31152163)
  • Body mass index ( 25673413)
  • Monocyte count ( 32888494)
  • Platelet count ( 32888494)
  • Platelet distribution width ( 32888494)
  • Schizophrenia ( 25056061 29483656)
Interacting Genes 156 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CENPJ CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CRELD1 CRKL CSNK1D CSNK2B CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GPS1 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PDHB PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPL3 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2 95 interacting genes: ABI1 ABI2 ABL1 ADAM15 ADGRL2 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CHN2 CRK CSNK1G2 CYFIP2 DAG1 DCC DLGAP4 DNM1 DOK1 DOK2 DRD3 DRD4 EFS EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB2 ERBB3 ERBB4 FASLG FCHO1 FGFR1 FLT1 FLT3 FRS2 GAB1 GAB2 GMPPA HOMEZ KDR KHDRBS1 KIAA1522 KIT LCP2 MAP4K1 MAP4K4 MET MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NHSL2 NPHS1 NTRK2 NUTM2F OLIG1 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PIK3AP1 PIK3R3 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SH2D1A SHANK3 SOCS1 SOCS7 SORBS3 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1
Entrez ID 85358 4690
HPRD ID 18979 02740
Ensembl ID ENSG00000251322 ENSG00000158092
Uniprot IDs A0A0S2Z4Y3 P16333
PDB IDs 2CI8 2CI9 2CUB 2JS0 2JS2 2JW4 5QU1 5QU2 5QU3 5QU4 5QU5 5QU6 5QU7 5QU8 5QUA
Enriched GO Terms of Interacting Partners?
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