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SHANK3 and PDHB
Number of citations of the paper that reports this interaction (PubMedID
21653829
)
98
Data Source:
BioGRID
(two hybrid)
SHANK3
PDHB
Description
SH3 and multiple ankyrin repeat domains 3
pyruvate dehydrogenase E1 subunit beta
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Postsynaptic Density
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuron Projection
Dendritic Spine
Neuron Spine
Postsynaptic Membrane
Ciliary Membrane
Nucleus
Nucleoplasm
Mitochondrion
Mitochondrial Matrix
Mitochondrial Pyruvate Dehydrogenase Complex
Pyruvate Dehydrogenase Complex
Molecular Function
Actin Binding
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SH3 Domain Binding
Synaptic Receptor Adaptor Activity
Ionotropic Glutamate Receptor Binding
Protein Self-association
Scaffold Protein Binding
Pyruvate Dehydrogenase (acetyl-transferring) Activity
Protein Binding
Pyruvate Dehydrogenase (NAD+) Activity
Biological Process
MAPK Cascade
Synapse Assembly
Learning
Memory
Striatal Medium Spiny Neuron Differentiation
Adult Behavior
Negative Regulation Of Actin Filament Bundle Assembly
Social Behavior
Vocal Learning
Negative Regulation Of Cell Volume
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Brain Morphogenesis
Positive Regulation Of Synapse Structural Plasticity
Positive Regulation Of Synaptic Transmission, Glutamatergic
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Development
Regulation Of Dendritic Spine Morphogenesis
Vocalization Behavior
Postsynaptic Density Assembly
AMPA Glutamate Receptor Clustering
NMDA Glutamate Receptor Clustering
Guanylate Kinase-associated Protein Clustering
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Glutamate Receptor Signaling Pathway
Regulation Of Long-term Synaptic Depression
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of AMPA Receptor Activity
Glucose Metabolic Process
Acetyl-CoA Biosynthetic Process From Pyruvate
Tricarboxylic Acid Cycle
Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism
Drugs
Pyruvic acid
NADH
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Extremely high intelligence (
29520040
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
26561523
)
Intelligence (MTAG) (
29326435
)
Mean platelet volume (
32888494
)
Memory dysfunction in frontotemporal lobe dementia (
29724592
)
Platelet count (
32888494
)
Apolipoprotein B levels (
32203549
)
Composite immunoglobulin trait (IgA x IgG/IgM) (
28628107
)
IgG levels (
28628107
)
LDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
28714469
)
Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) (
29310926
)
vWF levels (
30586737
)
Interacting Genes
156 interacting genes:
ABCC2
ABI1
ABI2
ACE2
ACTN2
ADGRL1
AGAP7P
ALDOA
ANKRD35
APP
ARHGAP44
ARPC2
ARPC5L
ATN1
BAIAP2
C1QBP
CA10
CALCOCO1
CAMK2B
CCT3
CENPJ
CEP72
CIBAR1
CLTA
CLU
CNKSR2
COPS5
COPS6
COQ5
CRELD1
CRKL
CSNK1D
CSNK2B
CTTN
CYP51A1
CYTIP
DBNL
DCTN2
DDB1
DLGAP1
DLGAP2
DLGAP3
DLGAP4
DNAJA3
DNM2
EFEMP1
EFEMP2
EID1
ELAVL1
ERI3
FAM13A
FBXO7
FKBP8
FRS3
FRYL
GAPDH
GOT1
GPR162
GPS1
GRB2
GRN
HAGH
HECW1
HGS
HNRNPK
HOMER3
ICA1
IGSF9
ITGBL1
ITSN1
JAG2
KHDRBS1
KIAA0232
LINGO1
LRRC73
LTBP3
LTBP4
LZTS2
LZTS3
MAPK1
MBIP
MBOAT7
MCRS1
MDH2
MEGF10
MEGF11
MEGF6
MIPOL1
MRM3
MT-CO2
MT-ND6
MYO5B
N4BP3
NCK1
NCKIPSD
NEFL
NGRN
NOTCH1
NOTCH2
NOTCH2NLA
NOTCH3
NR1D1
NRBF2
PAX6
PDHB
PFKL
PHF12
PHLDB1
PLEKHA4
PPHLN1
PPP1CC
PPP1R13L
PPP1R9B
PPP2R3B
PRMT2
QSOX1
RBM5
RPL3
RPS6KA1
RTN3
RUNDC3A
SCYL3
SETD2
SH3GL2
SH3GL3
SHANK1
SHARPIN
SIPA1
SLC48A1
SNRPN
SORBS2
SORBS3
SPAG5
SPTAN1
SRSF9
STK32C
SYNGAP1
SYT5
TCF25
TDRD7
TFIP11
THRAP3
TMEM14C
TNIP2
TRAF3
TRIM27
TRIM9
TRIP10
TSG101
TUBA1C
UCHL1
USP8
VIM
VPS18
WWP1
ZCCHC2
19 interacting genes:
ADORA2A
AKT1
ANXA7
ATXN7
CDKN1A
FCER1A
GNB2
GRB7
HSD17B10
ITGB1
PDHA1
PDHA2
PDHX
PFDN1
RAP1B
RCC1
SHANK3
TRIM63
TSC22D1
Entrez ID
85358
5162
HPRD ID
18979
01530
Ensembl ID
ENSG00000251322
ENSG00000168291
Uniprot IDs
A0A384MDR8
P11177
PDB IDs
1NI4
2OZL
3EXE
3EXF
3EXG
3EXH
3EXI
6CER
6CFO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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