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P4HA3 and ZC3H12A
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
P4HA3
ZC3H12A
Description
prolyl 4-hydroxylase subunit alpha 3
zinc finger CCCH-type containing 12A
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
P-body
Nucleus
Nucleoplasm
Cytoplasm
Rough Endoplasmic Reticulum
Cytoskeleton
Rough Endoplasmic Reticulum Membrane
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Extrinsic Component Of Endoplasmic Reticulum Membrane
Molecular Function
Procollagen-proline 4-dioxygenase Activity
Iron Ion Binding
Protein Binding
L-ascorbic Acid Binding
DNA Binding
Chromatin Binding
RNA Binding
MRNA Binding
MRNA 3'-UTR Binding
Endoribonuclease Activity
Exoribonuclease Activity
Ribonuclease Activity
Thiol-dependent Deubiquitinase
Protein Binding
MiRNA Binding
RNA Stem-loop Binding
MRNA 3'-UTR AU-rich Region Binding
Ribosome Binding
Metal Ion Binding
Biological Process
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay
Angiogenesis
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Defense Response To Virus By Host
Immune Response-activating Signal Transduction
Apoptotic Process
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Nervous System Development
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Muscle Cell Apoptotic Process
Positive Regulation Of Lipid Storage
Positive Regulation Of Cell Death
Protein Deubiquitination
Cell Differentiation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Cellular Response To Oxidative Stress
Cellular Response To Glucose Starvation
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Macrophage Activation
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation By Host Of Viral Genome Replication
Negative Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Protein Complex Oligomerization
Defense Response To Virus
Negative Regulation Of Cardiac Muscle Contraction
Positive Regulation Of MRNA Catabolic Process
3'-UTR-mediated MRNA Destabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
RNA Phosphodiester Bond Hydrolysis
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Response To Virus
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of P38MAPK Cascade
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein Deubiquitination
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Cellular Response To Sodium Arsenite
Cellular Response To Ionomycin
Cellular Response To Chemokine
Negative Regulation Of T-helper 17 Cell Differentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of MiRNA Catabolic Process
Pathways
Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS
Hippocampal atrophy (
25625606
)
Eyebrow thickness (
26926045
)
Mean corpuscular hemoglobin (
32888494
)
Red cell distribution width (
32888494
)
Interacting Genes
50 interacting genes:
ACOT8
ADRA2C
ANAPC11
ATN1
B9D2
BAG4
BLOC1S2
C1orf112
C1QTNF2
CERCAM
CKMT2
CLPP
CT55
CTAG1A
CTAG1B
CTNNBIP1
DTNBP1
FAM136A
GGA3
GPSM3
HGS
KRTAP19-5
KRTAP6-1
KRTAP8-1
LRP2BP
MAGEA2
MAGEA2B
MAGEC2
MCCD1
MEOX2
MSRA
NDN
NICN1
NUTM1
OIP5
P4HB
PROP1
PSMB4
RBFOX1
RUSC1
SCARA5
SERTAD1
SERTAD3
STMN3
TLE5
TOX2
VPS37C
WDR62
ZBTB7B
ZC3H12A
19 interacting genes:
AHSP
AIMP2
BTRC
CYFIP2
DNAJB13
EP300
HIF1A
IKBKG
IL6
IRAK2
KPNA2
P4HA3
SHBG
SMAD3
TANK
TRIM55
TRIM63
UBC
ZC3H12D
Entrez ID
283208
80149
HPRD ID
16413
08021
Ensembl ID
ENSG00000149380
ENSG00000163874
Uniprot IDs
Q7Z4N8
Q5D1E8
PDB IDs
3V32
3V33
3V34
Enriched GO Terms of Interacting Partners
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