P4HA3 and CLPP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		P4HA3	CLPP
Description		prolyl 4-hydroxylase subunit alpha 3	caseinolytic mitochondrial matrix peptidase proteolytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding L-ascorbic Acid Binding	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Identical Protein Binding ATPase Binding
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		Collagen biosynthesis and modifying enzymes
Drugs			N-Formylmethionine
Diseases
GWAS		Hippocampal atrophy ( 25625606)
Interacting Genes		50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A	19 interacting genes: ABI2 C14orf119 CHCHD3 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS STAT4 TNFSF9 TNPO3 TRIM54
Entrez ID		283208	8192
HPRD ID		16413	03074
Ensembl ID		ENSG00000149380	ENSG00000125656
Uniprot IDs		Q7Z4N8	Q16740
PDB IDs			1TG6 6BBA 6DL7 6H23
Enriched GO Terms of Interacting Partners?
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