ZC3H12A and AHSP

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
HPRD (two hybrid)

		ZC3H12A	AHSP
Description		zinc finger CCCH-type containing 12A	alpha hemoglobin stabilizing protein
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Rough Endoplasmic Reticulum Cytoskeleton Rough Endoplasmic Reticulum Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Extrinsic Component Of Endoplasmic Reticulum Membrane	Cytoplasm Hemoglobin Complex
	Molecular Function	DNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Endoribonuclease Activity Exoribonuclease Activity Ribonuclease Activity Thiol-dependent Deubiquitinase Protein Binding MiRNA Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Metal Ion Binding	Protein Binding Hemoglobin Binding Unfolded Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Immune Response-activating Signal Transduction Apoptotic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Nervous System Development Regulation Of Gene Expression Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Positive Regulation Of Cell Death Protein Deubiquitination Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation By Host Of Viral Genome Replication Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Complex Oligomerization Defense Response To Virus Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Virus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of P38MAPK Cascade Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Deubiquitination Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Sodium Arsenite Cellular Response To Ionomycin Cellular Response To Chemokine Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MiRNA Catabolic Process	Protein Folding Hemoglobin Metabolic Process Hemopoiesis Erythrocyte Differentiation Protein Stabilization
Pathways
Drugs			Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Eyebrow thickness ( 26926045) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		19 interacting genes: AHSP AIMP2 BTRC CYFIP2 DNAJB13 EP300 HIF1A IKBKG IL6 IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK TRIM55 TRIM63 UBC ZC3H12D	10 interacting genes: CLVS1 FKBP1A HBA2 POLR2M PSMB1 TMEM165 UBE3A VPS9D1 ZC3H12A ZNF20
Entrez ID		80149	51327
HPRD ID		08021	12052
Ensembl ID		ENSG00000163874	ENSG00000169877
Uniprot IDs		Q5D1E8	Q549J4 Q9NZD4
PDB IDs		3V32 3V33 3V34	1W09 1W0A 1W0B 1XZY 1Y01 1Z8U 3IA3 3OVU
Enriched GO Terms of Interacting Partners?
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