GPI and DCC

		GPI	DCC
Description		glucose-6-phosphate isomerase	DCC netrin 1 receptor
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Neuron Projection Ciliary Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytosol Plasma Membrane Axon Schaffer Collateral - CA1 Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding	Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding
	Biological Process	In Utero Embryonic Development Mesoderm Formation Positive Regulation Of Immunoglobulin Production Carbohydrate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Learning Or Memory Positive Regulation Of Endothelial Cell Migration Response To Estradiol Response To Progesterone Response To Testosterone Erythrocyte Homeostasis Response To Immobilization Stress Response To Muscle Stretch Glucose Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Cadmium Ion Glucose 6-phosphate Metabolic Process	Neuron Migration Apoptotic Process Axonogenesis Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Collateral Sprouting Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Neuron Death Negative Regulation Of Dendrite Development
Pathways		TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs		alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-phospho-D-arabinohydroxamic acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate D-erythrose 4-phosphate Fructose-6-phosphate Copper Artenimol
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular volume ( 32888494)	Age at first sexual intercourse ( 27089180 34211149) Alcoholism (alcohol use disorder factor score) ( 21529783) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Benign prostatic hyperplasia ( 30988330) Body mass index ( 28892062) Body mass index (ever vs never smoking interaction) ( 23192594) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Brain morphology (MOSTest) ( 32665545) Chronic back pain ( 30261039) Coenzyme Q10 levels ( 27149984) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 27089181 33859377 29700475) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling miserable ( 29500382) Gallbladder cancer ( 22318345) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) Homeostasis model assessment of insulin resistance ( 33381925) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30591961) Lung function (FVC) ( 30061609 30804560) Mood instability ( 31168069 29187730) Mosquito bite size ( 28199695) Multisite chronic pain ( 33830993 31194737) Neurociticism ( 29500382) Nickel levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Putamen volume ( 29147026) Response to exercise (triglyceride level interaction) ( 26491034) Response to fenofibrate (total cholesterol levels) ( 27002377) Response to mTOR inhibitor (everolimus) ( 24009623) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 33169155 30285260) Short-term memory (digit-span task) ( 30741946) Smoking behaviour (cigarettes smoked per day) ( 27393504) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Subcortical brain region volumes ( 25607358) Survival in colorectal cancer (distant metastatic) ( 26586795) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		7 interacting genes: AMFR CSNK2A1 DCC IGFBP3 LINC01554 PARP14 PCNA	38 interacting genes: ADORA2B AFDN-DT ALDOB ANP32B APPL1 AR ARG2 BARD1 CASP3 CASP9 CORO2A CTSV FBP1 FECH GPI HEMGN MAPK3 MAZ NARS1 NCK1 NSDHL NTN1 PITPNA POLR2E PTK2 RASA1 RPL5 SERPINB2 SFRP2 SIAH1 SIAH2 TBC1D2 TDRD7 TMOD1 TNNI1 TRMO TSTD2 TULP4
Entrez ID		2821	1630
HPRD ID		01394	00391
Ensembl ID		ENSG00000105220	ENSG00000187323
Uniprot IDs		A0A2U3TZU2 B4DE36 P06744	P43146 Q49AK4
PDB IDs		1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI	2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83
Enriched GO Terms of Interacting Partners?
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