DCC and SERPINB2

		DCC	SERPINB2
Description		DCC netrin 1 receptor	serpin family B member 2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Axon Schaffer Collateral - CA1 Synapse Integral Component Of Postsynaptic Density Membrane	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Neuron Migration Apoptotic Process Axonogenesis Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Collateral Sprouting Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Neuron Death Negative Regulation Of Dendrite Development	Negative Regulation Of Endopeptidase Activity Wound Healing Fibrinolysis Negative Regulation Of Apoptotic Process
Pathways		Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO	Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Urokinase Tenecteplase Lanoteplase
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Alcoholism (alcohol use disorder factor score) ( 21529783) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Benign prostatic hyperplasia ( 30988330) Body mass index ( 28892062) Body mass index (ever vs never smoking interaction) ( 23192594) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Brain morphology (MOSTest) ( 32665545) Chronic back pain ( 30261039) Coenzyme Q10 levels ( 27149984) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 27089181 33859377 29700475) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling miserable ( 29500382) Gallbladder cancer ( 22318345) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) Homeostasis model assessment of insulin resistance ( 33381925) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30591961) Lung function (FVC) ( 30061609 30804560) Mood instability ( 31168069 29187730) Mosquito bite size ( 28199695) Multisite chronic pain ( 33830993 31194737) Neurociticism ( 29500382) Nickel levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Putamen volume ( 29147026) Response to exercise (triglyceride level interaction) ( 26491034) Response to fenofibrate (total cholesterol levels) ( 27002377) Response to mTOR inhibitor (everolimus) ( 24009623) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 33169155 30285260) Short-term memory (digit-span task) ( 30741946) Smoking behaviour (cigarettes smoked per day) ( 27393504) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Subcortical brain region volumes ( 25607358) Survival in colorectal cancer (distant metastatic) ( 26586795) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Asthma ( 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hen's egg allergy ( 29051540) Hip circumference adjusted for BMI ( 28552196) Systolic blood pressure ( 29208002)
Interacting Genes		38 interacting genes: ADORA2B AFDN-DT ALDOB ANP32B APPL1 AR ARG2 BARD1 CASP3 CASP9 CORO2A CTSV FBP1 FECH GPI HEMGN MAPK3 MAZ NARS1 NCK1 NSDHL NTN1 PITPNA POLR2E PTK2 RASA1 RPL5 SERPINB2 SFRP2 SIAH1 SIAH2 TBC1D2 TDRD7 TMOD1 TNNI1 TRMO TSTD2 TULP4	9 interacting genes: APP CDC42 DCC IRF3 PLAU PRPF8 PSMB1 RB1 UBE3A
Entrez ID		1630	5055
HPRD ID		00391	01420
Ensembl ID		ENSG00000187323	ENSG00000197632
Uniprot IDs		P43146 Q49AK4	P05120
PDB IDs		2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83	1BY7 1JRR 2ARQ 2ARR
Enriched GO Terms of Interacting Partners?
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