GNAZ and RAP1GAP

Number of citations of the paper that reports this interaction (PubMedID 10593970)
19

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		GNAZ	RAP1GAP
Description		G protein subunit alpha z	RAP1 GTPase activating protein
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane	Golgi Membrane Cytoplasm Early Endosome Cytosol Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway	Adaptive Immune Response Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly Negative Regulation Of GTP Binding Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor
Pathways		G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events ADORA2B mediated anti-inflammatory cytokines production	Rap1 signalling RET signaling
Drugs
Diseases
GWAS		Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 18391951) Processed meat consumption ( 32066663)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		16 interacting genes: ADORA1 APP DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	16 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A SDHB ZBTB12
Entrez ID		2781	5909
HPRD ID		00746	02609
Ensembl ID		ENSG00000128266	ENSG00000076864
Uniprot IDs		P19086 Q8IY73	A0A024RAB5 P47736 X6R8W7
PDB IDs			1SRQ 3BRW
Enriched GO Terms of Interacting Partners?
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