VPS41 and GSDME

		VPS41	GSDME
Description		VPS41 subunit of HOPS complex	gasdermin E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Microtubule Cytoskeleton Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane Lysosomal HOPS Complex	Cytoplasm Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Protein Self-association Metal Ion Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding
	Biological Process	Protein Targeting To Vacuole Endosome To Lysosome Transport Cellular Response To Starvation Macroautophagy Endosomal Vesicle Fusion Regulated Exocytosis Late Endosome To Lysosome Transport	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Drugs
Diseases
GWAS		Breast cancer and/or colorectal cancer ( 29698419) Cognitive performance ( 19734545)
Interacting Genes		14 interacting genes: AKTIP AP3D1 APP ARID1A ARL8B GSDME HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B	11 interacting genes: AHR C1GALT1 GARS1 GP1BB GPNMB HNRNPA2B1 ITGB1BP1 PTN TBX19 TIFA VPS41
Entrez ID		27072	1687
HPRD ID		10402	02996
Ensembl ID		ENSG00000006715	ENSG00000105928
Uniprot IDs		P49754	A0A024RA58 A4FVA8 O60443
PDB IDs
Enriched GO Terms of Interacting Partners?
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