GSDME and VPS41

		GSDME	VPS41
Description		gasdermin E	VPS41 subunit of HOPS complex
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Lysosome Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Microtubule Cytoskeleton Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane Lysosomal HOPS Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding	Protein Binding Microtubule Binding Identical Protein Binding Protein Self-association Metal Ion Binding
	Biological Process	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Targeting To Vacuole Endosome To Lysosome Transport Cellular Response To Starvation Macroautophagy Endosomal Vesicle Fusion Regulated Exocytosis Late Endosome To Lysosome Transport
Pathways		Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Drugs
Diseases
GWAS			Breast cancer and/or colorectal cancer ( 29698419) Cognitive performance ( 19734545)
Interacting Genes		11 interacting genes: AHR C1GALT1 GARS1 GP1BB GPNMB HNRNPA2B1 ITGB1BP1 PTN TBX19 TIFA VPS41	14 interacting genes: AKTIP AP3D1 APP ARID1A ARL8B GSDME HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B
Entrez ID		1687	27072
HPRD ID		02996	10402
Ensembl ID		ENSG00000105928	ENSG00000006715
Uniprot IDs		A0A024RA58 A4FVA8 O60443	P49754
PDB IDs
Enriched GO Terms of Interacting Partners?
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