GHR and CISH

Number of citations of the paper that reports this interaction (PubMedID 12586763)
3

Data Source:
HPRD (in vitro, in vivo)

		GHR	CISH
Description		growth hormone receptor	cytokine inducible SH2 containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex
	Molecular Function	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Endocytosis Receptor Signaling Pathway Via JAK-STAT Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Response To Food Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Response To Morphine Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Response To Interleukin-1 Negative Regulation Of Neuron Death	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs		Somatotropin Pegvisomant Somatrem Somapacitan
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 28552196 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		45 interacting genes: AP2A1 BTRC CISH CLCC1 CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2	18 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR GPX1 HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		2690	1154
HPRD ID		02971	03897
Ensembl ID		ENSG00000112964	ENSG00000114737
Uniprot IDs		A0A087X0H5 A0A087X162 P10912	Q9NSE2
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD
Enriched GO Terms of Interacting Partners?
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