GHR and PTPN9

Number of citations of the paper that reports this interaction (PubMedID 12907755)
20

Data Source:
BioGRID (pull down, far western blotting)

		GHR	PTPN9
Description		growth hormone receptor	protein tyrosine phosphatase non-receptor type 9
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex	Nucleoplasm Cytoplasm Neuron Projection Terminus
	Molecular Function	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Endocytosis Receptor Signaling Pathway Via JAK-STAT Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Response To Food Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Response To Morphine Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Response To Interleukin-1 Negative Regulation Of Neuron Death	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	Interleukin-37 signaling
Drugs		Somatotropin Pegvisomant Somatrem Somapacitan
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 28552196 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)	Estimated glomerular filtration rate ( 31015462) Height ( 25429064 31562340 33713608 20189936) Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 30297969)
Interacting Genes		45 interacting genes: AP2A1 BTRC CISH CLCC1 CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2	46 interacting genes: AGTRAP AQP6 ARL13B ARL6IP1 ATP5PF BSND CCR2 CDR1 CERS4 CMTM4 CMTM5 COQ3 CPLX4 CREB3 CREB3L1 DERL2 EBP FAM114A2 FKBP7 GET1 GHR GJB1 GORAB HSD17B11 HSD17B13 LIME1 LMNA MAL2 NSF PBX3 PEX12 PLIN3 REEP6 RTN3 SCAMP1 SLC16A13 SLC30A8 SLC7A1 SPAG4 STX6 SYP TMCO2 TMEM80 TMEM86B TMX2 YIF1A
Entrez ID		2690	5780
HPRD ID		02971	02864
Ensembl ID		ENSG00000112964	ENSG00000169410
Uniprot IDs		A0A087X0H5 A0A087X162 P10912	P43378 Q6IQ43
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD	2PA5 4GE2 4GE5 4GE6 4ICZ 6KZQ 6L03
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?