IL36RN and CNOT4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IL36RN	CNOT4
Description		interleukin 36 receptor antagonist	CCR4-NOT transcription complex subunit 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Nucleus Cytosol CCR4-NOT Complex
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Inflammatory Response To Antigenic Stimulus Inflammatory Response Signal Transduction Antifungal Humoral Response Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination
Pathways		Interleukin-36 pathway	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Stroke ( 26089329)	Appendicular lean mass ( 33097823) Clostridioides difficle infection ( 33841421) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Meat-related diet ( 32066663) Numerical cognitive ability ( 31620175)
Interacting Genes		18 interacting genes: AGR2 AP3M1 CNOT4 CRACR2B DDIT4L HPCA INCA1 IRAK4 MCM6 REL SH2B2 SKIL SSBP2 SSBP3 SSBP4 UBL4B ZKSCAN4 ZNF512B	18 interacting genes: CNOT1 CNOT2 CNOT3 CNOT6 CNOT8 EP300 IL36RN KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		26525	4850
HPRD ID		16112	05369
Ensembl ID		ENSG00000136695	ENSG00000080802
Uniprot IDs		A0A024R518 Q9UBH0	A0A024R776 A0A024R781 A0A024R785 O95628
PDB IDs		4P0J 4P0K 4P0L	1E4U 1UR6
Enriched GO Terms of Interacting Partners?
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