CNOT4 and CNOT6

Number of citations of the paper that reports this interaction (PubMedID 30692204)
7

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CNOT4	CNOT6
Description		CCR4-NOT transcription complex subunit 4	CCR4-NOT transcription complex subunit 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol CCR4-NOT Complex	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Nuclear Receptor Coactivator Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination	Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of Transcription, DNA-templated Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Clostridioides difficle infection ( 33841421) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Meat-related diet ( 32066663) Numerical cognitive ability ( 31620175)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Ovarian cancer ( 30557369) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		18 interacting genes: CNOT1 CNOT2 CNOT3 CNOT6 CNOT8 EP300 IL36RN KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	4 interacting genes: CNOT4 CNOT7 CNOT8 PABPC1
Entrez ID		4850	57472
HPRD ID		05369	12341
Ensembl ID		ENSG00000080802	ENSG00000113300
Uniprot IDs		A0A024R776 A0A024R781 A0A024R785 O95628
PDB IDs		1E4U 1UR6
Enriched GO Terms of Interacting Partners?
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