IL36RN and CRACR2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IL36RN	CRACR2B
Description		interleukin 36 receptor antagonist	calcium release activated channel regulator 2B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Cytoplasm
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding	Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Inflammatory Response To Antigenic Stimulus Inflammatory Response Signal Transduction Antifungal Humoral Response Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide	Store-operated Calcium Entry Cellular Protein Localization Regulation Of Store-operated Calcium Entry
Pathways		Interleukin-36 pathway
Drugs
Diseases
GWAS		Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Stroke ( 26089329)	Body mass index ( 29273807)
Interacting Genes		18 interacting genes: AGR2 AP3M1 CNOT4 CRACR2B DDIT4L HPCA INCA1 IRAK4 MCM6 REL SH2B2 SKIL SSBP2 SSBP3 SSBP4 UBL4B ZKSCAN4 ZNF512B	15 interacting genes: APP CA13 CCDC187 DNAAF4 IDH1 IL36RN LNX1 PSMB3 RIN1 TCEANC TSGA10IP TSHZ2 TXN2 USP2 ZBTB25
Entrez ID		26525	283229
HPRD ID		16112	14645
Ensembl ID		ENSG00000136695	ENSG00000177685
Uniprot IDs		A0A024R518 Q9UBH0	Q8N4Y2
PDB IDs		4P0J 4P0K 4P0L
Enriched GO Terms of Interacting Partners?
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