USP22 and ATXN7

Number of citations of the paper that reports this interaction (PubMedID 24981860)
22

Data Source:
BioGRID (pull down, affinity chromatography technology)

		USP22	ATXN7
Description		ubiquitin specific peptidase 22	ataxin 7
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Coactivator Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination
Pathways		HATs acetylate histones Ub-specific processing proteases	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mosquito bite size ( 28199695)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)
Interacting Genes		17 interacting genes: AASDHPPT ATXN7 ATXN7L3 B9D1 BAG4 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MTUS2 PSME1 PTGS2 RCAN1 SCFD1 SIRT1 UBC	65 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CPOX CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GNAT1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PDHB PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SERINC3 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 SYNJ2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF
Entrez ID		23326	6314
HPRD ID		19411	06365
Ensembl ID		ENSG00000124422	ENSG00000163635
Uniprot IDs		Q9UPT9	O15265 Q9UPD8
PDB IDs			2KKR
Enriched GO Terms of Interacting Partners?
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