ATXN7 and NUP62

Number of citations of the paper that reports this interaction (PubMedID 21078624)
26

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ATXN7	NUP62
Description		ataxin 7	nucleoporin 62
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Spindle Pole Nuclear Envelope Annulate Lamellae Nuclear Pore Nucleoplasm Cytoplasm Centrosome Nuclear Membrane Nuclear Pore Central Transport Channel Mitotic Spindle Flemming Body Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding Phospholipid Binding Structural Constituent Of Nuclear Pore Kinesin Binding Signaling Receptor Complex Adaptor Activity Hsp70 Protein Binding SH2 Domain Binding Ubiquitin Binding Protein-containing Complex Binding PTB Domain Binding Hsp90 Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination	RNA Export From Nucleus Protein Import Into Nucleus Mitotic Metaphase Plate Congression Centrosome Cycle Mitotic Centrosome Separation Cell Surface Receptor Signaling Pathway Spermatogenesis Cell Aging Cell Death Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Centriole Replication MRNA Transport Regulation Of Mitotic Spindle Organization Centriole Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome
Pathways		HATs acetylate histones Ub-specific processing proteases	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)
Interacting Genes		65 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CPOX CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GNAT1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PDHB PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SERINC3 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 SYNJ2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	98 interacting genes: ABI2 ADAM15 AGR3 ARFIP2 ATF7IP2 ATXN7 BFSP1 BLOC1S6 C14orf119 C1orf216 CAVIN3 CCDC121 CCDC146 CCDC150 CCDC153 CCHCR1 CENPU CEP57L1 CLIC1 CRCT1 CYTH2 DDX3X DGCR6 DPPA3 DTNB DYNLT1 FABP3 GOPC GORASP2 GTF2E2 HAUS1 HGS HSF2 HSF4 HSPB11 IDH1 IFT20 IK IKBIP IPO5 ISCU KANSL1 KIFC3 KLHL32 KPNA1 KPNA2 KPNB1 KRT1 KRT20 KRT3 KRT6A KRT6B KRT75 LMO2 LNX1 MUC1 MXD3 MYO15B NAPSA NFX1 NOSIP NUP153 NUP214 NUP54 NUP58 NUP88 NUP98 NUTF2 NXF1 NXF2 OGT OIP5 OTUD6A PBX2 PELI2 PHF21A PIN1 PTMA RANBP2 SMARCA2 SMARCE1 SNAPC5 SP1 SSC5D SUOX THAP1 TLE4 TRAF3 TRIML2 TXLNA TXN USHBP1 WASHC3 XPO1 XPO6 ZNF432 ZNF473 ZNF91
Entrez ID		6314	23636
HPRD ID		06365	05782
Ensembl ID		ENSG00000163635	ENSG00000213024
Uniprot IDs		O15265 Q9UPD8	A0A024QZF1 P37198
PDB IDs		2KKR	2H4D 5IJN 5IJO
Enriched GO Terms of Interacting Partners?
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