ATXN7 and NOC2L

Number of citations of the paper that reports this interaction (PubMedID 21078624)
26

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ATXN7	NOC2L
Description		ataxin 7	NOC2 like nucleolar associated transcriptional repressor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Noc1p-Noc2p Complex Noc2p-Noc3p Complex
	Molecular Function	Protein Binding	Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Nucleosome Binding Histone Binding DNA-binding Transcription Factor Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Apoptotic Process Chromatin Assembly Cellular Response To UV Negative Regulation Of Histone Acetylation Ribosomal Large Subunit Biogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		HATs acetylate histones Ub-specific processing proteases	Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)	California verbal learning test score ( 31596458) Pancreatic cancer ( 29422604)
Interacting Genes		65 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CPOX CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GNAT1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PDHB PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SERINC3 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 SYNJ2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	11 interacting genes: APP ATN1 ATXN7 H2AC18 H2BP1 H3-4 H4-16 LRIF1 PPP1CA PTGFR RBFOX1
Entrez ID		6314	26155
HPRD ID		06365	13166
Ensembl ID		ENSG00000163635	ENSG00000188976
Uniprot IDs		O15265 Q9UPD8	Q9Y3T9
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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