CSTF2T and SMYD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CSTF2T	SMYD3
Description		cleavage stimulation factor subunit 2 tau variant	SET and MYND domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Binding MRNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Pre-mRNA Cleavage Required For Polyadenylation	Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus
Pathways		mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Mammographic density (non-dense area) ( 25342443)	Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)
Interacting Genes		22 interacting genes: AKAP8L ATP23 CDSN COL17A1 CPSF1 CTAG1A CTAG1B CTDSP1 FAM168B FOXI1 FOXJ2 GOLGA2 HGS LASP1 PKNOX2 SMYD3 SPAG8 STH TLE5 TOX2 UBQLN1 UBQLN4	22 interacting genes: APP CAMK2B CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K SCCPDH SHC3 TRIT1 VANGL1 ZNF557
Entrez ID		23283	64754
HPRD ID		09900	12297
Ensembl ID		ENSG00000177613	ENSG00000185420
Uniprot IDs		Q9H0L4	B3KN46 Q9H7B4
PDB IDs			3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 7BJ1
Enriched GO Terms of Interacting Partners?
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