SMYD3 and TRIT1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		SMYD3	TRIT1
Description		SET and MYND domain containing 3	tRNA isopentenyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Mitochondrion Mitochondrial Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding	Nucleic Acid Binding ATP Binding Zinc Ion Binding TRNA Dimethylallyltransferase Activity
	Biological Process	Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus	TRNA Modification Mitochondrial TRNA Modification
Pathways		PKMTs methylate histone lysines	tRNA modification in the nucleus and cytosol tRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)	Refractive error ( 32231278)
Interacting Genes		22 interacting genes: APP CAMK2B CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K SCCPDH SHC3 TRIT1 VANGL1 ZNF557	6 interacting genes: ANKS1A COL6A3 HGH1 OGT SHE SMYD3
Entrez ID		64754	54802
HPRD ID		12297	18226
Ensembl ID		ENSG00000185420	ENSG00000043514
Uniprot IDs		B3KN46 Q9H7B4	Q3T7C7 Q53F11 Q9H3H1
PDB IDs		3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 7BJ1
Enriched GO Terms of Interacting Partners?
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