GMNN and SIX3

Number of citations of the paper that reports this interaction (PubMedID 14973488)
89

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		GMNN	SIX3
Description		geminin DNA replication inhibitor	SIX homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Signaling Receptor Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Regulation Of Transcription By RNA Polymerase II Brain Development Visual Perception Proximal/distal Axis Specification Neuroblast Differentiation Telencephalon Development Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Alcohol and nicotine co-dependence ( 22488850) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol use disorder ( 30940813) Blood sugar levels ( 29403010) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Clozapine-induced myocarditis in schizophrenia ( 32066683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fasting blood glucose ( 33842983 29621232) Fasting glucose ( 34059833) Fasting plasma glucose ( 25187374) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General risk tolerance (MTAG) ( 30643258) Glycated hemoglobin levels ( 34059833 29170429) Hemoglobin A1c levels ( 29403010) Intraocular pressure ( 29785010 31959993 30054594) Irritable mood ( 29500382) Lung cancer ( 28604730) Metabolite levels ( 21909109) Myopia ( 27182965) Optic disc size ( 31809533) Problematic alcohol use ( 32451486) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Self-reported risk-taking behaviour ( 30271922) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 32499647)
Interacting Genes		34 interacting genes: ARNT AURKA CASP3 CCDC146 CDC20 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SHANK2 SIX3 SMARCA4 ZNF250 ZNF439	7 interacting genes: EYA1 GMNN NR4A3 PAX6 TLE1 TLE3 TLE5
Entrez ID		51053	6496
HPRD ID		06783	04756
Ensembl ID		ENSG00000112312	ENSG00000138083
Uniprot IDs		A0A024QZY7 O75496	O95343
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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