CARD16 and CARD8

Number of citations of the paper that reports this interaction (PubMedID 11821383)
57

Data Source:
HPRD (in vitro, in vivo)

		CARD16	CARD8
Description		caspase recruitment domain family member 16	caspase recruitment domain family member 8
Image		No pdb structure
GO Annotations	Cellular Component	Protein-containing Complex Protease Inhibitor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Inflammasome Complex NLRP3 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Kinase Binding Identical Protein Binding CARD Domain Binding Caspase Binding	Protein Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Protein Binding Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Cellular Response To UV-C Inhibition Of Cysteine-type Endopeptidase Activity	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response To Virus Self Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways			Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: CARD17 CARD8 CASP1 RIPK2	9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3
Entrez ID		114769	22900
HPRD ID		16740	16425
Ensembl ID		ENSG00000204397	ENSG00000105483
Uniprot IDs		Q5EG05	A0A024QZD3 Q9Y2G2
PDB IDs			4IKM 6K9F 6XKJ
Enriched GO Terms of Interacting Partners?
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